Researcher

The current project represents pioneering efforts to understand the important interaction between genes and neuronal excitability using an appropriate iPSC model.
This project aims at experimental methodologies that will include electrophysiological characterization (single-cell intrinsic properties and synaptic communication using double patch) and 2-photon calcium imaging in acute slices and in vivo. Functional characterization will be complemented by structural analysis, post hoc immunolabeling, and expression assays. Additional phenotyping will also be performed in cell culture. The candidate will join the group experienced with iPSC differentiation. The derived cells will be subjected to rigorous validation utilizing already established protocols. These will include transcriptome analysis, immunohistochemistry, high-end microscopy, FACS, neurite analysis, synaptic protein staining analysis and synapse density. Moreover, the candidate will assess whether functional characteristics of the iPSC model can predict EEG indices of neuronal excitability and synaptic communication in SCZ and BD.

• The applicant must hold a strong PhD degree in neuroscience or equivalent and a documented genuine interest in the type of project we offer.
• The successful candidate should document experience in patch clamp recordings (voltage clamp, current clamp, whole-cell, excised patch) and other electrophysiological methods, as well as interest to work on investigation of cellular- and molecular-level mechanisms underlying SCZ and BP.
• Strong background in at least one of the following is strongly desired: Cell biology/molecular biology and/or neurophysiology/electrophysiology.
• Background in microscopic imaging is desirable.
• Strong analytical and problem solving skills and attention to details
• The candidate should be proficient in spoken and written English
• Personal skills will be emphasized. Especially, the candidate should be able to work independently and interactively in a team setting, be motivated and responsible, and also have a great work capacity and enthusiasm for research.
  

We offer an exciting research environment with a multidisciplinary profile and large opportunities for academic development. Favorable pension arrangements
Attractive welfare arrangements

The application must include:

• Application letter, including motivation for applying for the position
• CV (summarizing education, positions, academic work-scientific publications and other relevant activity)
• A complete list of any publications and academic work
• Copies of educational certificates and transcripts of records